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lab profile
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Angelika Stollewerk Queen Mary, University of London
School of Biological and Chemical Sciences
Mile End Road
London, London E1 4NS
United Kingdom
a.stollewerk@qmul.ac.uk
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| PI: |
YES |
| Taxa Studied: |
Invertebrate Animals |
| Techniques Employed: |
Degenerate PCR, Bioinformatics/Sequence Analysis, In Situ Hybridization, Antibody Staining, RNA interference(RNAi), Sectioning for Histology, Sectioning for Electron Microscopy, Scanning Electron Microscopy, Epifluoresence Microscopy, Confocal Microscopy, Transgenesis |
| Research Description: |
My research addresses the question how neural development has been modified during evolution to give rise to the high diversity of adult nervous systems in aeurthropods (insects, crustaceans, chelicerates, myriapods). Evolutionary modifications of neural networks can in principle be achieved during different processes of neural development: (1) by changes in the generation of neural precursors (early neurogenesis) (2) by changes in the establishment of neural precursor identity, (3) by changes in the proliferation of individual progenitor lineages, (4) by modifications of axonal pathfinding, i.e. changes in the expression of guidance molecules or changes in the intrinsic properties of pioneer neurons. We are analysing neurogenesis in all four arthropod groups and outgroups to the euarthropods (e.g. onychophorans) - from the formation of neural precursors up to the establishment of neuronal networks - using morphological and molecular tools in order to understand (1) in what way the developmental mechanisms have been modified in the individual arthropod groups and (2) to distinguish derived characters of neurogenesis that can be used for resolving euarthropod relationships. |
| Lab Web Page: |
http://stollewerk.co.uk |
| Willing to Host Undergraduates: |
YES |
| Actively Seeking Undergraduates: |
YES |
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